59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
59878-57-8, General procedure: A mixture of magnolol (266mg, 1mmol), NaOH (40mg, 1mmol) and 37% formaldehyde solution (0.61mL) in ethanol (20mL) was stirred for 24hat room temperature. The mixture was extracted with ethyl acetate and the organic phase was washed with saturated salt water, dried with anhydrous Na2SO4, filtered, concentrated under reduced pressure, and purified by flash column chromatography on silica gel, to afford the pure product 12a. 12a (148mg, 0.5mmol) was dissolved in 10mL of CH2Cl2, the reaction mixture was cooled to 0C and SOCl2 (119mg, 1mmol) was added. The mixture was washed with saturated sodium bicarbonate solution, dried with anhydrous Na2SO4, filtered, concentrated under reduced pressure to give 12b. A 25mL round-bottomed flask was charged with 12b (100mg, 0.32mmol), different nitrogen heterocycles (0.32mmol), CsCO3 (140.4mg, 0.43mmol) and catalytic amount of KI. To this mixture were added MeCN (10mL) and the temperature was maintained at 80C overnight. The reaction mixture was cooled to room temperature and added H2O (10mL), followed by extraction with ethyl acetate. The combined organic extracts were washed with saturated salt water, dried over Na2SO4, filtered, concentrated under reduced pressure, and purified by column chromatography on silica gel, to afford the products A1-A22, respectively.
The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Tang, Huan; Zhang, Yongguang; Li, Dan; Fu, Suhong; Tang, Minghai; Wan, Li; Chen, Kai; Liu, Zhuowei; Xue, Linlin; Peng, Aihua; Ye, Haoyu; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 190 – 205;,
Piperazine – Wikipedia
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