With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.
115619-01-7, A mixture of 5 (0.49g, 2.39mmol), H2O (0.75ml) and AcOH (3ml) was mixed with the 83 (0.15g, 3.13mmol) and refiuxed for overnight. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 9: 1, Rf = 0.25) to afford 87 (0.60g, 80.20%) as a pale orange solid. 1H-NMR (300MHz, CDCl3): delta 1.16 (t, J= 7.2 Hz, 3H), 2.48 (q, J= 7.2 Hz, 2H), 2.64 (t, J= 5.1 Hz, 4H), 2.81 (d, J= 5.4 Hz, 3H), 3.22 (t, J= 5.1 Hz, 4H), 4.86 (s, 1H), 5.54 (s, 1H), 6.69 (s, 1H), 6.95 (d, J= 9.0 Hz, 2H), 7.18 (d, J= 8.7 Hz, 2H), 8.14 (s, 1H).
115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics