59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59878-57-8
1- (3-carboxybenzyl) thieno [2,3-D] pyrimidine-2,4 (1H, 3H) -dione (0.2 g, 0.66 mmol) Tripyrrolidinium bromide phosphonium hexafluorophosphate (PyBrOP, 0.46 g, 0.99 mmol), 1-cyclopropanecarbonylpiperazine (0.1 g, 0.66 mmol), N, N-diisopropylethylamine (DIPEA, 0.17 g, 1.32 mmol), dichloromethane (5 mL) was added to the reaction flask, Stir overnight at room temperature. The reaction mixture was added with methylene chloride (5 mL), water (5 mL), extracted, The organic layer was washed with water (3 mL), dried, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (mobile phase CH2Cl2 / CH3OH 50/1) to give the final product Synthesis of 1- (3- (4-cyclopropylcarbonylpiperazine-1-carbonyl) benzyl) thieno [2,3- D] pyrimidine-2,4 (1H, 3H) Dione (I-1) as a white solid (0.2 g, yield 68.9%),
59878-57-8 1-(Cyclopropylcarbonyl)piperazine 2064235, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Shanghai Xunhe Pharmaceutical Technology Co., Ltd.; Zheng Yongyong; Jin Hua; Zhou Feng; Huang Meihua; Meng Xin; (28 pag.)CN107286174; (2017); A;,
Piperazine – Wikipedia
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