5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5521-39-1, To a stirred solution of 21 3-(2,6-dichlorophenyl)-7-(methylthio)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.2 g, 0.58 mmol, 1.0 eq) in 5 mL 24 toluene 25 m-CPBA (0.251 g, 1.46 mmol, 2.5 eq) was added under stirring and resulting mixture was allowed to stir at rt for 30 min. Further, 604 2-(4-(4-aminophenyl)piperazin-1-yl)ethan-1-ol (0.129 g, 0.58 mmol, 1.0 eq) and 27 DIPEA (0.302 g, 2.33 mmol, 4 eq) were added and the reaction was allowed to stir at rt for 12 h. The reaction was monitored by LCMS. After completion reaction was quenched with 7 water and extracted with ethyl acetate (5 mL×3). The combined organic layer was washed with brine solution (10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product which was purified by flash chromatography (MeOH: CH2Cl2 1-10%) to afford 607 3-(2,6-dichlorophenyl)-7-((4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)-2,3-dihydro-4H-pyrimido[5,4-e][1,3]oxazin-4-one (0.008 g, 10%) as white solid. (0628) LCMS: 515 [M+1]+ (0629) 1H NMR (400 MHz, DMSO-d6): delta 10.18 (s, 1H), 8.78 (s, 1H), 8.20 (s, 1H), 7.65 (d, J=8.33 Hz, 2H), 7.51 (d, J=7.45 Hz, 2H), 6.92 (d, J=8.33 Hz, 2H), 5.71 (br s, 2H), 4.43 (br s, 2H), 3.53 (d, J=6.14 Hz, 2H), 3.17 (d, J=5.26 Hz, 1H), 3.09 (br s, 1H), 1.23 (br s, 1H), 1.16 (d, J=10.09 Hz, 1H).
5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
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