55112-42-0, 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N-(2-CHLORO-4-FLUOROPHENYL)-LS-PYRAZOLE-3-CARBOXAMIDE (50 mg, 209 UMOL, 1 equiv. ; see step (a) above) was mixed with the hydrochloride salt of 4-methyl-piperazine-1-carbonyl chloride (83 mg, 410 pmol, 2 equiv. ) and DMAP (50 mg, 410 mumol, 2 equiv. ) in toluene (5 mL) at 90C. The reaction mixture was left stirring for 16 h and then cooled. The precipitate from the reaction mixture was collected and recrystallised from EtOH/EtOAc to yield the hydrochloride salt of the title compound (a white powder). 0.5 M NaOH (AQ.) and ethyl acetate were added to the salt. The organic phase was dried and concentrated to afford the free base of the title compound as an off-white solid., 55112-42-0
The synthetic route of 55112-42-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BIOLIPOX AB; MCNEENEY, Stephen, Phillip; WO2004/80999; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics