With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78818-15-2,Benzyl 3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step 1 5-Methoxy-3,6-dihydro-2H-pyrazine-1-carboxylic Acid Benzyl Ester Na2CO3 (45.3 g, 0.43 mol) was added in one portion to a stirred solution of benzyl 3-oxopiperazine-1-carboxylate (5 g, 21.4 mmol) in DCM (200 mL) at 0 C. under N2. The resulting suspension was stirred at 0 C. for 10 min and then trimethyloxonium tetrafluoroborate (11.0 g, 74 mmol) was added in one portion. The resulting mixture was warmed to room temperature and stirred for 6 h before being poured into H2O (200 mL) and separated. The aqueous layer was then extracted with DCM (200 mL). The combined organic extracts were washed with H2O (3*100 mL) and brine (100 mL), dried and concentrated under reduced pressure. The crude residue was further purified by column chromatography on silica using 5% MeOH in DCM as the eluent to give the imino ether (2.5 g, 47%). 1H NMR (360 MHz, CDCl3) delta 2.99 (3H, s), 3.36 (2H, br, s), 3.72 (2H, t, J=5.4 Hz), 4.14 (2H, s), 5.14 (2H, s), 7.28-7.45 (5H, m).
78818-15-2, As the paragraph descriping shows that 78818-15-2 is playing an increasingly important role.
Reference：
Patent; Bryant, Helen Jane; Chambers, Mark Stuart; Jones, Philip; MacLeod, Angus Murray; Maxey, Robert James; US2003/125333; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics