163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 5-bromo-2-nitro-pyridine (500 mg, 2.46 mmol) and (‘R)-3-methyl-piperazine-1 -carboxylic acid tert-butyl ester (592 mg, 2.96 mmol) in 1 ,4-dioxane is added Cs2C03 (963 mg, 2.96 mmol) and XantPhos (71.3 mg, 0.12 mmol). The mixture is degassed for 5 min. Pd2(dba)3 (123 mg, 0.12 mmol) is added, degassed for 5 min. and stirred for 15 h at reflux. The reaction mixture is filtered through Celite and washed with DCM (50ml_ x 2). The combined organic layers are washed with brine, dried with Na2S04, filtered and concentrated under reduced pressure. The resulting residue is purified by silica gel chromatography (0602) (EtOAc/hexane) to afford the title product. (0603) Yield: 400 mg (50%), 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BRUNETTE, Steven; CUI, Jianwen; LOWE, Michael D.; SARKO, Christopher Ronald; SURPRENANT, Simon; TURNER, Michael Robert; WU, Xinyuan; SMITH KEENAN, Lana Louise; BOUYSSOU, Thierry; (183 pag.)WO2019/158572; (2019); A1;,
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