120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Sodium hydride (72 mg, 3 [MMOL)] is added to a solution of 7-chloro-4-quinolone (359 mg, 2 [MMOL)] in DMF. After 1 h [AT 40 °C N-PHENYL (TRIFLUOROMETHYLSULFON)] imide (1.0 g, 2.8 [MMOL)] and, 1 h later, 1-tert-butoxycarbonyl-3-methylpiperazine (1.8 g, 8 [MMOL)] is added. The reaction mixture is stirred at 80 [°C] for 2 days, concentrated, diluted with EtOAc, washed with water and brine, dried [(NA2SO4),] and concentrated. The residue is purified by reversed phase HPLC with water-MeCN-TFA to give the title product. 1H NMR (CD3) [8 1.] 0 (d, 3H), 1.5 (s, 9H), 2.9 (m, [1H),] 3.3-3. 8 (m, 6H), 6.9 (d, 1H), 7.5 (m, [1H),] 8.1 (m, 2H), [8.] 8 (d, 1H).
120737-59-9, The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/2960; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics