With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
The MH1-004 (0.100 g, 0.403 mmol) and 1-boc-4-(4?-aminophenyl)piperazine (0.112 g, 0.403 mmol) were mixed in EtOH (1 ml) in a 5 ml microwave vial, and heated to 150 C for 20 minutes in a microwave, after which a drop of concentrated HCl was added, before returning it to the microwave for a further 20 minutes at 150C. The solid precipitate produced was filtered out of the mixture and washed with a saturated solution of NaHCO3, and the solid product again collected by filtration. The resulting white solid was dried under reduced pressure (0.074 g, 0.190 mmol, 47%). HPLC-MS {m/z 195.2 [(M+2H)/2]2} 97.8% [R = 6.99 mm, Grad. MeOH – water 5-95 (with 0.1% formic acid) 20mm]; ?H NMR (400 MHz, DMSO-d6) oe 8.93 (s, 1H), 7.86 (s, 1H), 7.50 (d, J 9.0 Hz, 2H), 7.00(t, J= 5.7 Hz, 1H), 6.79 (d, J= 9.1 Hz, 2H), 4.10-4.03 (m, 1H), 3.75 (dd, J 13.6, 7.5 Hz, 1H),3.60 (dd, J 14.5, 7.4 Hz, 1H), 3.41 (t, J 6.0 Hz, 3H), 2.96 -2.88 (m, 4H), 2.84 – 2.76 (m,4H), 1.94 – 1.72 (m, 3H), 1.64- 1.53 (m, 1H). LC-MS (ESI+) m/z 389.19 (M+H) HRMS(ESI+) m/z calculated for C,9H26ClN6O (M+H) 389.1851, found, 389.1860.
170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; MAHAJAN, Nupam, P.; MAHAJAN, Kiran, N.; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; WO2015/21149; (2015); A1;,
Piperazine – Wikipedia
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