With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112257-12-2,tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Commercially available 4-nitroimidazole (0.55 g, 4.9 mmol) was dissolved in 2 mL of freshly distilled DMF, under N2, and cooled to 0 C. Sodium hydride (0.14 g, 5.9 mmol) was added to the reaction and stirred for 30 min before a dropwise addition of tert-butyl 4-(2-bromoacetyl)piperazine-1-carboxylate (1.50 g, 4.9 mmol) dissolvedin 2 mL of DMF. The mixture was slowly warmed to room temperature and stirred overnight. Addition of 10 mL of water caused a white precipitate to form. The solid was filtered and dried under reduced pressure overnight to afford tert-butyl 4-(2-(4-nitro-1H-imidazol-1-yl)acetyl)piperazine-1-carboxylate 8b (1.26 g, 3.7 mmol,76%); mp: 197-199 C. 1H NMR (400 MHz, CDCl3) delta 7.82-7.81 (d,J 1.5 Hz, 1H), 7.45-7.44 (d, J 1.4 Hz, 1H), 4.86 (s, 2H), 3.65-3.63(m, 2H), 3.56-3.54 (m, 2H), 3.50-3.47 (m, 4H), 1.48 (s, 9H); 13C NMR (100 MHz, CDCl3) delta 163.1, 154.6, 148.2, 137.1, 120.9, 81.1, 48.8, 45.0,42.5, 28.5; HRMS (ESI-TOF): [M+H]+ Calc’d for C14H22N5O5 m/z 340.1621. Found, m/z 340.1607.
112257-12-2, 112257-12-2 tert-Butyl 4-(2-bromoacetyl)piperazine-1-carboxylate 15829155, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Abuteen, Akram; Zhou, Feifei; Dietz, Christopher; Mohammad, Innus; Smith, Michael B.; Zhu, Quing; Dyes and Pigments; vol. 126; (2016); p. 251 – 260;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics