With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2815-34-1,trans-2,5-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
A mixture of 2, 2′-Bis [(DIPHENYLPHOSPHINO)-1,’-BINAPHTHYL] (0.068g, 0. 109mmol) and palladium acetate (0.016g, 0. [072MOL)] in toluene (5ml) were heated to [80C.] To this was added the product from example 316, step 1 [(1- [3- (4-IODO-PHENOXY)-PROPYL]-] piperidine) (0.5g, 1. 45mmol) pre-dissolved in toluene (5ml), (2S, 5R)-2, 5-dimethyl- piperazine (0.20g 1. [74MMOL)] predissolved in toluene (5ml), followed by sodium [TERT-] butoxide (0.20g, 2. [02MOL).] The mixture was heated at [100C] for 6 hours. After cooling to room temperature the reaction mixture was diluted with ethyl acetate, washed with water (x3), brine [(X1),] dried over magnesium sulphate and concentrated in vacuo. The residue was purified on silica gel eluting with a mixture of 0.88 ammonia solution : methanol : [DICHLOROMETHANE] (0.5 : 4.5 : 95) to furnish the title compound (0.98g, 20%); MS (ES+) m/e 332 [M+H] [+.]
2815-34-1, The synthetic route of 2815-34-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXO GROUP LIMITED; WO2004/35556; (2004); A1;,
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