438631-77-7, (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 7-bromo-4,6-dichloro-3-nitroquinoline (4.97 g, 15.44 mmol) in THF (100 mL) was added 1-tert-butyl 3-methyl (3R)-piperazine-1,3-dicarboxylate (4.9 g, 20.07 mmol) followed by DIPEA (8.07 mL, 46.31 mmol) and reaction mixture heated at reflux overnight. Further 1-tert-butyl 3-methyl (3R)-piperazine-1,3-dicarboxylate (0.943 g, 0.25 eq) was added, along with further DIPEA (1.35 mL, 0.5 eq) and the reaction mixture heated at reflux for a further 24 h. The reaction mixture was partially concentrated and partitioned between water and EtOAc. Layers were separated, the organic layer washed with water and the combined aqueous layers were back extracted with EtOAc. The combined organic layers were dried (phase separator) and concentrated in vacuo to afford crude material as a dark brown oil. This was purified by flash silica chromatography (0 to 18% EtOAc in heptane) to afford 1-tert-butyl 3-methyl (3R)-4-(7-bromo-6-chloro-3-nitroquinolin-4-yl)piperazine-1,3-dicarboxylate (5.2 g, 64%) as an orange foam; 1H NMR (400 MHz, DMSO, 30 C.) 1.44 (9H, s), 3.29 (2H, s), 3.5-3.58 (3H, m), 3.6-3.69 (1H, m), 3.73 (1H, dd), 3.78-3.9 (1H, m), 4.02-4.2 (1H, m), 4.3-4.38 (1H, m), 8.49 (1H, s), 8.52 (1H, s), 9.11 (1H, s); m/z: ES+ [M+H]+ 529, 531.
438631-77-7, The synthetic route of 438631-77-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics