With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 6 or 7 (0.68-0.74 mmol) in 3 mL of n-BuOH kept in a PV with stirring, cyclic amines (1.02-1.11 mmol) was added. The sealed PV was placed in an oil bath at 145-150 C and stirred for 50-60 min. The solvent was evaporated in vacuo with the aid of DCM and the residue was re-dissolved in 2:1 EtOAc/DCM and washed successively with saturated NaHCO3 and NaCl solution (1 x 15 mL), respectively. The aqueous layer was washed with EtOAc (3 x 5 mL) and the organic layer was dried over anhydrous MgSO4 then filtered. The solution was evaporated in vacuo and purified using silica gel column chromatography with appropriate eluents (EtOAc/hexanes 3:1 and 1:3 v/v, respectively or 9:1 DCM/EtOAc) to afford either solid or semisolid products., 13484-40-7
As the paragraph descriping shows that 13484-40-7 is playing an increasingly important role.
Reference：
Article; Mohamed, Tarek; Yeung, Jacky C.K.; Rao, Praveen P.N.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5881 – 5887;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics