With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
Part II – Synthesis of [(S)-4-(3-chloro-benzenesulfonyl)-2-(4-methyl-3-oxo-piperazin-l- ylmethyl)-3,4-dihydro-2H-benzo[l,4]oxazin-6-yl]-carbamic acid tert-butyl ester [0340] A suspension of 3-chloro-benzenesulfonic acid (i?)-6-tert-butoxycarbonylamino-4-(3- chloro-benzenesulfonyl)-3,4-dihydro-2H-benzo[l,4]oxazin-2-yl methyl ester (63 mg, 0.1 mmol), N, N-diisopropylethylamine (0.2 mmol), l-methyl-piperazin-2-one, hydrochloride salt (30 mg, 0.2 mmol) and potassium iodide (5 mg) in THF (0.5 mL) and N-methyl pyrrolidinone (0.5 mL) was heated in a sealed tube for 12 hours at 80 C. After cooling, the mixture was partitioned between water and ethyl acetate. The organic layer was separated, washed with brine, saturated aqueous NaHC03 and concentrated. The residue was purified by column chromatography on silica gel to provide [(5)-4-(3-chloro-benzenesulfonyl)-2-(4- methyl-3-oxo-piperazin-l-ylmethyl)-3,4-dihydro-2H-benzo[l,4]oxazin-6-yl]-carbamic acid tert-butyl ester. LCMS (ESI) m/z 551., 109384-27-2
The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine; WO2013/169704; (2013); A2;,
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