Month: May 2021

59878-57-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.

(Formula 5-4: methyl 4-((N-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-4-(cyclopropanecarbonyl)piperazine-1-carboxamido)methyl)benzoate)[1167][1168]Compound ofFormula 5-3(methyl 4-(((3-(benzo[d][1,3]dioxol-5-yl)phenyl)((4-nitrophenoxy)carbonyl)amino)methyl)benzoate; 0.180 g, 0.342 mmol) was dissolved in dimethylformamide (2 mL), and then cyclopropyl(piperazin-1-yl)methanone(0.158 g, 1.03 mmol) and potassium carbonate (0.142 g, 1.03 mmol) were added and stirred at 50 C for 16 hours. After completion of the reaction, the organic layer was extracted with ethyl acetate and saturated ammonium chloride aqueous solution, dehydrated with anhydrous magnesium sulfate, and then filtered. The filtrate was concentrated under reduced pressure, and then the residue was purified and concentrated by column chromatography (silica; ethyl acetate/hexane= 30%) to give the desired compound ofFormula 5-4(0.096 g, 52%) in the form of a yellow liquid.

The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Changsik; YANG, Hyun-Mo; CHOI, Hojin; KIM, Dohoon; KIM, Soyoung; HA, Nina; LIM, Hyojin; KO, Eunhee; YOON, Seongae; BAE, Daekwon; WO2014/178606; (2014); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59702-07-7, 26.18 g Sodium triacetoxyborohydride are added at 5° C. to a solution of 10.0 g 4-methyl-3-oxo-piperazine, 13.51 g 1,4-dioxa-spiro[4,5]decan-8-one, 5.65 ml acetic acid and 200 ml dichloromethane. After 23 hours stirring at ambient temperature 100 ml dichloromethane and 100 ml 4N sodium hydroxide solution are added. The phases are separated and the organic phase is evaporated down. The residue is purified by chromatography.Mass spectrum (ESI+): m/z=255 [M+H]+

The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/22505; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

103-76-4, N-(2-Hydroxyethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-(piperazin-1-yl)ethan-1-ol (0.943 mL, 7.681 mmol) and di-tert-butyl dicarbonate (1.760 g, 8.065 mmol) in tetrahydrofuran (5 mL) was stirred at the room temperature for 18 hr. Then, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (SiO2, 24 g cartridge; methanol / dichloromethane = 0 % to 10 %) to give tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate as colorless oil (1.750 g, 98.9 %)., 103-76-4

103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Jaekwang; HAN, Younghue; KIM, Yuntae; MIN, Jaeki; BAE, Miseon; KIM, Dohoon; JIN, Seokmin; KYUNG, Jangbeen; (191 pag.)WO2017/18805; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

115761-79-0, 1-(2,4-Difluorophenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a flask chargedwith 50 mL of CH3CNwas added 2.5mmol of compound6 and appropriate piperazine derivatives (3a-w, 1.5 eq.) and thereaction mixturewas refluxed for 10-38 h until the complete consumptionof starting material as detected by TLC. After the completion of thereaction, the reaction mixture was treated with ice and the resultingsolid was filtered and washed with water (2 × 25 mL). The residuewas purified with a silica gel column chromatography and was elutedwith dichloromethane: methanol (40:1) to afford corresponding products7a-w in 49-82% of yields

115761-79-0, As the paragraph descriping shows that 115761-79-0 is playing an increasingly important role.

Reference：
Article; Patel, Rahul V.; Mistry, Bhupendra; Syed, Riyaz; Rathi, Anuj K.; Lee, Yoo-Jung; Sung, Jung-Suk; Shinf, Han-Seung; Keum, Young-Soo; European Journal of Pharmaceutical Sciences; vol. 88; (2016); p. 166 – 177;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438631-77-7,(R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.,438631-77-7

To (R)-1-tert-butyl 3-methylpiperazine-1,3-dicarboxylate (1.2 g, 4.9 mmol, ASW Med Chem Inc) in MeCN and MeOH (1:1, 100 mL) was added formaldehyde (37% aqueous, 13.2 mL, 177 mmol), followed by the addition of sodium triacetoxyborohydride (5.20 g, 24.5 mmol). The mixture was stirred for about 15 min at ambient temperature. AcOH (5.6 mL, 98 mmol) was added drop-wise and the mixture was stirred for about 1 h. The solvent was removed under reduced pressure and the residue was dissolved in DCM (100 mL) and neutralized using aqueous 2 N NaOH. Saturated aqueous NaHCO3 (50 mL) was added and the layers were separated. The organic layer was washed with brine (50 mL), dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The crude material was purified by silica gel chromatography eluting with a gradient of 20-80% EtOAc/heptane to afford (R)-1-tert-butyl 3-methyl 4-methylpiperazine-1,3-dicarboxylate (1.1 g, 85%): LC/MS (Table 2, Method a) Rt=1.91 min; MS m/z: 259 (M+H)+.

438631-77-7 (R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 6558432, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ABBOTT LABORATORIES; US2009/312338; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

11 g (2.35 g, 10 mmol) was dissolved in a methanol solvent,Under nitrogen protection, 200 mg of Pd / C was added,And then through the H2 reaction,6h after the reaction is complete.The filtrate was collected by filtration, and concentrated to give 1.89 g of a solid. Yield 92%., 70261-81-3

70261-81-3 1-Methyl-4-(4-nitrobenzyl)piperazine 677795, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; Nantong University; Ling, Yong; Mou, Jiefei; Xu, Qibing; Feng, Jiao; Zhu, Peng; Liu, Ji; Wang, Tingting; Ge, Xiang; Liang, Shanshan; (26 pag.)CN106432235; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57184-25-5, 1-(Cyclopropylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57184-25-5, Methanesulfonic acid 2-(lH-indol-4-yl)-4~morpholin~4-yl-thieno[3,2- d]pyrimidin-6-ylmethyl ester, amine and triethylamine were mixed together in DMF and stirred at room temperature. When the reaction was judged to be complete, the solvent was removed under reduced pressure, the residue dissolved in DMSO and purified by preparative HPLC. The chromatographic solvents were removed under reduced pressure to afford the product > 85% purity.

57184-25-5 1-(Cyclopropylmethyl)piperazine 965875, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.

21655-48-1, A solution of methyl 2-chloropyrimidine-5-carboxylate (535 mg, 3.10 mmol) in dichloromethane (7.50 ml) was added to a stirred solution of (2S,6R)-2,6-dimethylpiperazine (354 mg, 3.10 mmol) and N-ethyl-N-propan-2-ylpropan-2-amine (1.35 ml, 7.75 mmol) in dichloromethane (7.24 ml) at room temperature under nitrogen. The resulting solution was stirred at ambient temperature for 3 h. The reaction mixture was concentrated under reduced pressure and the crude product was purified by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 7M NH3/MeOH and evaporated to dryness to afford impure product. The impure material was purified by silica column chromatography, eluting with a gradient of 0 to 5percent 7M NH3/MeOH in dichloromethane. Pure fractions were evaporated to dryness to afford the desired compound (740 mg, 95percent) as a white solid. 1H NMR (399.9 MHz, DMSO-d6) delta 1.02-1.04 (6H, m), 2.33 (1H, s), 2.43-2.46 (2H, m), 2.64-2.69 (2H, m), 3.81 (3H, s), 4.62-4.66 (2H, m), 8.77 (2H, s). MS: m/z 251 (MH+).

21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; ASTRAZENECA AB; US2008/153812; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373608-48-1,tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of intermediate compound E1 (1 .1 g), triethylamine (0.674 ml_) and 2-oxo-2H-chromen-4-yl trifluoromethanesulfonate (1 .2 g), prepared as described in step 5 of the preparation of compound 51 , in acetonitrile (20 ml_) was heated to 705C for 1 hour. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between dichloromethane and a brine/sodium bicarbonate mixture (1 :1 ). The mixture was filtered through a hydrophobic frit (Phase Separator) washing with dichloromethane. The organic phase was evaporated under reduced pressure and the residue was chromatographed on silica gel (SNAP50) eluting with a gradient of EtOAc in cyclohexane to give 700 mg of tert-butyl 4-{3-[(2-oxo-2H-chromen- 4-yl)amino]propyl}piperazine-1 -carboxylate intermediate compound E2 (700 mg, Y=44%). LC-MS (M-H+) = 388.3, 373608-48-1

As the paragraph descriping shows that 373608-48-1 is playing an increasingly important role.

Reference：
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; GAROFALO, Barbara; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra; CORSO, Gaia; CAVARISCHIA, Claudia; FURLOTTI, Guido; IACOANGELI, Tommaso; (161 pag.)WO2016/96686; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

697305-48-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.697305-48-9,1-(4-Fluorophenyl)piperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of ethyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate methanesulfonate 4 (606 mg, 1.8 mmol) and CDI (476 mg, 2.9 mmol) in MeCN (10 mL) was added dropwise DIEPA (0.67 mL) and stirred at 0 C for 30 min. 8a (410 mg, 1.8 mmol) and DIPEA (0.35 mL) was added to the mixture, and stirred ar room temperature overnight. The mixture was added sat. NaHCO3 aq., and extracted with AcOEt. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by column chromatography to give 6a as a amorphous solid. The obtained material was dissolved in EtOH (5 mL) and was added dropwise 4 N NaOH (1.4 mL). The resulting mixture was stirred room temperature overnight. After evaporation of the solvent, the residue was acidified with 1 N HCl and the resulting precipitate was collected by filtration, washed with H2O to give 7a (630 mg, 81%) as a colorless solid.

697305-48-9 1-(4-Fluorophenyl)piperazin-2-one hydrochloride 67085022, apiperazines compound, is more and more widely used in various fields.

Reference：
Article; Banno, Yoshihiro; Sasaki, Shigekazu; Kamata, Makoto; Kunitomo, Jun; Miyamoto, Yasufumi; Abe, Hidenori; Taya, Naohiro; Oi, Satoru; Watanabe, Masanori; Urushibara, Tomoko; Hazama, Masatoshi; Niwa, Shin-ichi; Miyamoto, Saku; Horinouchi, Akira; Kuroshima, Ken-ichi; Amano, Nobuyuki; Matsumoto, Shin-ichi; Matsunaga, Shinichiro; Bioorganic and Medicinal Chemistry; vol. 25; 21; (2017); p. 5995 – 6006;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics