Month: May 2021

1152367-80-0, (S)-1,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: (S)-1,3-Dimethylpiperazine dihydrochloride (0.16 g, 0.85 mmol) was added in oneportion to (2S)-2-bromo-N-(3-{2-[(3-methoxy-1-methyl-1 H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1 Hindol-7-yl)propanamide (0.2 g, 0.43 mmol, Intermediate 32) and potassium carbonate (0.24 g, 1.7 mmol) in DMF (2 mL) at 0C. The resulting solution was stirred at 25C for 16 hours. The crude product was purified by preparative HPLC (X Bridge C18, 5 tim, 19×150 mm; Mobile Phase A: water0.05% TFA, Mobile Phase B: acetonitrile; Flow rate: 20 mLmin; Gradient: 20%B70%B in 10 mm; 254 nm) to afford (2R)-2-[(2S)-2,4-dimethylpiperazin-1-yl]-N-(3-{2-[(3-methoxy-i -methyl-i H-pyrazol-4-yl)amino]pyrimidin-4-yl}-i H-indol-7-yl)propanamide (49 mg, 23%, Example 1) as a white solid;, 1152367-80-0

As the paragraph descriping shows that 1152367-80-0 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAND, Annika, Birgitta, Margareta; GRIMSTER, Neil, Patrick; KAWATKAR, Sameer; KETTLE, Jason, Grant; NILSSON, Magnus, K.; RUSTON, Linette, Lys; SU, Qibin; VASBINDER, Melissa, Marie; WINTER-HOLT, Jon, James; WU, Dedong; YANG, Wenzhan; GRECU, Tudor; MCCABE, James; WOESSNER, Richard, Donald; CHUAQUI, Claudio, Edmundo; (175 pag.)WO2017/50938; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

325145-35-5, (S)-tert-Butyl 2-ethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 15 as Boc-Protected ER-890963 To a solution of 14 (13.9 g, 31.77 mmol) and TEA (8.86 mL, 63.541 mmol) in DMA (89 mL) at rt was added dropwise commercially available (S)-tert-butyl 2-ethylpiperazine-1-carboxylate (7.49 g, 34.95 mmol) over 5-min period. The reaction mixture was stirred at 110¡ã C. for 12 h to completion after which time the reaction was cooled to rt. The reaction was concentrated to remove DMA followed by dilution with DCM (30 mL). The resultant organic solution was washed two times with water (30 mL each), brine (30 mL), and dried over MgSO4. The crude was filtered, concentrated in vacuo, and purified over silica gel (SNAP 340 g eluting 10percent to 30percent EtOAc in heptene, TLC heptane/EtOAc=3/1, rt=0.6) gave 5-((2S,6R)-2-(((S)-4-(3,3-dimethylbutanoyl)-3-ethylpiperazin-1-yl)methyl)-6-methylmorpholino)quinoline-8-carbonitrile or Boc-protected ER-890963 (12.27 g, 24.15 mmol, 76percent yield) as yellow powder after concentration of the combined desired fractions and drying in vacuo., 325145-35-5

As the paragraph descriping shows that 325145-35-5 is playing an increasingly important role.

Reference£º
Patent; CARLSON, ERIC; HANSEN, HANS; HAWKINS, LYNN; ISHIZAKA, SALLY; MACKEY, MATTHEW; SCHILLER, SHAWN; OGAWA, CHIKAKO; DAVIS, HEATHER; US2015/105370; (2015); A1;,
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Piperazines – an overview | ScienceDirect Topics

129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In 9 parallel batches, A mixture of tert-butyl 2-methyl piperazine-l,2-dicarboxylate (1.0 g, 4.09 mmol), (4-fluorophenyl)boronic acid (1.72 g, 12.28 mmol), Copper(II) acetate (1.5 g, 8.19 mmol), pyridine (647 mg, 8.19 mmol) and sodium bicarbonate (688 mg, 8.19 mmol) in dichloromethane (50 ml) was stirred at ambient temperature under 02 (balloon) for 60 h, at which time LCMS indicated the reaction had gone to completion. The combined solutions were concentrated under reduced pressure. The residue was dissolved in ethyl acetate (50 mL), washed with water (2 x 40 mL) and concentrated. The crude product was purified by silica gel chromatography column (Hexanes/ethyl acetate = 5: 1) to give the title compound (9.8 g, yield 79%) as a brown oil. NMR (400 MHz, CDC13): delta 6.91 -6.80 (m, 2 H), 6.80-6.62 (m, 2 H), 4.86-4.68 (m, 1 H), 4.05-3.88 (m, 2 H), 3.77 (s, 3 H), 3.37-3.15 (m, 2 H), 2.90-2.86 (m, 1 H), 2,77-2.68 (m, 1 H), 1.49-1.40 (m, 9 H). LCMS M/Z (M+H) 338., 129799-15-1

The synthetic route of 129799-15-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; BELLON, Steven, F.; BURDICK, Daniel, J.; COTE, Alexandre; CRAWFORD, Terry; DAKIN, Les, A.; HSIAO-WEI TSUI, Vickie; HEWITT, Michael, Charles; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F., Anthony; TANG, Yong; TAYLOR, Alexander, M.; WANG, Shumei; (251 pag.)WO2016/77375; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

182181-38-0, 3-Fluoro-4-(piperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Combine 1-(4-cyano-2-fluorophenyl)piperazine (1.57 g, 7.6 mmol) and Et3N (1.28 ml, 9.2 mmol) in CH2Cl2 (10 ml) and add Boc2O (1.67 g, 7.6 mmol). Stir 1 h and wash with satd. NaHCO3. Dry (MgSO4) and concentrate to obtain the crude carbamate as a yellow solid., 182181-38-0

182181-38-0 3-Fluoro-4-(piperazin-1-yl)benzonitrile 596113, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Corporation; US2004/220194; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of 4-fluoronitrobenzene (5.00 g, 35.4 mmol) in THF (50 mL), 1- isopropylpiperazine (4.54 g, 35.4 mmol) and K2CO3 (7.35 g, 53.2 mmol) are added. The reaction mixture is stirred at room temperature overnight. The solvent is removed under reduced pressure and the residue is partitioned between EtOAc and water. The organic layer is washed with brine, dried (MgSO4), filtrered and the solvent is removed under reduced pressure. The crude compound is purified by silica gel column chromatography using 99:1 and 98:2 DCM:NH3 (7 M in MeOH) to give the title compound (8.2g, 94percent)

The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALAPAGOS N.V.; WO2008/65199; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture of 2,4,5-trifluorobenzonitrile (1.0 g, 6.4 mmol), (S)-tert-butyl 2- methylpiperazine-1-carboxylate (1.53 g, 7.6 mmol) and K2C03 (2.64 g, 19.1 mmol) in MeCN (20 mL) were stirred at 80 C for 16 h. The mixture was then filtered, washed with MeCN (5 mL x 2), concentrated, and purified by chromatography (PE:EtOAc = 2:3) to afford (S)-tert-butyl 4-(2- cyano-4,5-difluorophenyl)-2-methylpiperazine-1-carboxylate (1.8 g, 84%) as a white solid. MS (EI+, m/z): 338.2 [M+H]t

169447-70-5, As the paragraph descriping shows that 169447-70-5 is playing an increasingly important role.

Reference£º
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 – Methyl-piperazin-2-one hydrochloride (0.844 mmol, 127 mg) in dichloromethane was put on a column of Si-Carbonate (Silicycle, 1 g) and eluation with dichloromethane gave the free base 1 -methyl-piperazin-2- one. To this compound in 2-propanol (1 ml) were subsequently added 4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexanone (0.649 mmol, 200 mg) and aluminium isopropoxide (1.469 mmol, 300 mg) and the mixture was stirred at 60 C for one hour. Sodium triacetoxyborohydride (1.298 mmol, 275 mg) was added and the mixture was stirred at 60 C overnight. Then the reaction mixture was diluted with dichloromethane and water, the dichloromethane layer isolated by a phase separation filter and concentrated in vacuo. The crude product was was purified by column chromatography (silica gel; gradient of dichloromethane to dichloromethane / methanol 92/8) to give 4-((trans)-4-(1-bromo-8-methylimidazo[1 ,5- a]pyrazin-3-yl)cyclohexyl)-1 -methylpiperazin-2-one (50 mg)., 109384-27-2

As the paragraph descriping shows that 109384-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (27-1)( 400.0 mg, 1.44 mmol) in DMF (1.0 mL) were added 3-bromopiperidine-2,6-dione (1-2) (552 mg,5 2.88 mmol) and DIPEA (795 J.L, 4.31 mmol) and the reaction mixture was stirred at roomtemperature for 16 hours. It was diluted with saturated aqueous NaHC03 solution and extractedwith 20% IP A/DCM. Organic layer was dried over sodium sulfate and concentrated. Crudematerial was purified by column chromatography using (0%-2% MeOH/DCM) to afford tert-butyl4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperazine-1-carboxylate (27-3) (300 mg, 772J.mol,10 53.6 %) as offwhite solid. LC/MS (ES+): m/z 389 [M+H]+, 170911-92-9

As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.

Reference£º
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Christoper, G.; HENDERSON, James, A.; LIANG, Yanke; HE, Minsheng; DUPLESSIS, Martin; CHEN, Chi-Li; (791 pag.)WO2018/237026; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57260-71-6,tert-Butyl piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

The piperazine-1-carboxylic acid tert-butyl ester (1.50 g, 8.06 mmol) was dissolved in 30 mL of acetonitrile.Trifluoroethyl trifluoromethanesulfonate (2.25 g, 9.68 mmol), cesium carbonate (3.94 g, 12.10 mmol) was added and stirred at room temperature for 3 hr. After the reaction is complete, filter, filterThe solvent was evaporated under reduced pressure to give the title compound.

57260-71-6, As the paragraph descriping shows that 57260-71-6 is playing an increasingly important role.

Reference£º
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Ge Chongxun; Huang Yiqiang; Cao Chen; Li Qingqing; Hou Shaohua; (63 pag.)CN108276382; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.

[Referential Example 16] 1-Methylpiperazin-2-one trifluoroacetic acid salt 4-Methyl-3-oxopiperazine-1-carboxylic acid tert-butyl ester (0.308 g) obtained in step 2) of Referential Example 15 was dissolved in dichloromethane (6 mL). Trifluoroacetic acid (3 mL) was added to the resultant mixture at room temperature, followed by stirring for 1.5 hours. The reaction solvent was evaporated under reduced pressure, and the residue was dried, to thereby give the title compound (0.485 g, quantitative amount). 1H-NMR(400MHz,CDCl3-CD3OD(15:1))delta:2.98(3H,s), 3.39(2H,t-like,J=6.1Hz), 3.54(2H,t-like,J=6.1Hz), 3.72(2H,s). MS(EI) m/z:114(M+).

109384-27-2, The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1762568; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics