With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13484-40-7,1-(2-Methoxyethyl)piperazine,as a common compound, the synthetic route is as follows.
Example 121-(2-(2-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea [Show Image] To a solution of 1-(2-(2-chloropyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea (227 mg) in ethanol (1.0 mL), 1-(2-methoxyethyl)piperazine (80 mg) and N,N-diisopropylethylamine (0.5 mL) were added, and the resulting mixture was stirred at room temperature for 4 days. Saturated aqueous sodium bicarbonate solution was added to the reaction mixture, which was then extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous sodium sulfate, and then evaporated under reduced pressure. The obtained residue was purified by amine-silica gel column chromatography (ethyl acetate/n-hexane = 1/1 – 2/1) to obtain the desired product (212 mg, yield: 76.5%). 1H-NMR (CDCl3):delta 8.13 (d 1H J = 5.6 Hz) 7.34-7.06 (m 8H) 6.20 (s 1H) 5.99 (s 1H) 5.90 (d 1H J = 5.6 Hz) 5.28 (t 1 H J = 5.9 Hz) 4.34 (d 2H J = 5.9 Hz) 3.68 (br 4H) 3.51 (t 2H J = 5.6 Hz) 3.35 (s 3H) 2.57 (t 2H J = 5.6 Hz) 2.46-2.44 (m 4H) 2.37 (s 3H) 1.32 (s 9H) MS (ESI):599 (M+H+)
13484-40-7, The synthetic route of 13484-40-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TORAY INDUSTRIES, INC.; EP1970375; (2008); A1;,
Piperazine – Wikipedia
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