With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-66-2,(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Step D: (3R)-tert-butyl4-(2-(2-chloro:-3-cyano-4-fluorophenyl)-2-hydroxyethyl)-3-(hydroxymethyl)piperazine-1-carboxylate; 2-Chloro-6-fluoro-3-( oxiran-2-yl)benzonitrile (9.1 g,46 mmol) and (R)-tert-butyl3-(hydroxymethyl)piperazine-1-carboxylate (14.9 g, 69.1 mmol)were dissolved in ethanol (1 05 mL) and dispensed into 9 sealed tubes then microwaved at140C for 1 h. The combined reaction mixture was concentrated and purified through a 330gISCO Redi-sep column with 50%-100 ethyl acetate/hexane solvent system to yield the title compound., 278788-66-2
278788-66-2 (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820286, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics