With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
(RS) tert-butyl 4-(3,5-dichloropyridin-4-yl)-2-methyl-piperazine-l-carboxylate(RS) tert-butyl 2-methylpiperazine-l-carboxylate (2.2Og, 10.98 mmol) and 3,4,5 trichloropyridine were combined and heated at 100 0C for 64 hours. The reaction mixture was cooled to ambient temperature and purified by flash column chromatography (4Og silica column, eluting with DCM containing 0 – 10% of methanol) to give the title compound as a brown oil, 5.87 g, 100 %, 1H NMR (400 MHz, DMSOd6) delta 1.22 (3H, d), 1.42 (9H, s), 2.74- 3.09 (5H, m), 3.76 – 3.77 (2H, m), 7.96 (2H, s), m/z 346 (M+H)+ [I]., 120737-78-2
120737-78-2 tert-Butyl 2-methylpiperazine-1-carboxylate 15087784, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135427; (2007); A1;,
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