Some tips on 31166-44-6

31166-44-6, 31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of N-(benzyloxycarbonyl)piperazine (220 mg, 1 mmol) in dichloromethane (10 mL) was slowly added to the stirred solution of triphosgene (110 g, 0.37 mmol) in dichloromethane (2 mL) over a period of 30 min using a syringe pump. After 30 further min of stirring, a solution of 2 (398 mg, 1.2 mmol) and diisopropylethylamine (DIEA, 0.38 mL, 2.2 mmol) in DCM/EtOH (120 mL, 4:1) was added in one portion. The reaction mixture was stirred for 2 hours at room temperature. After evaporation of solvent under vacuum, the residue was purified by silica gel chromatography to give 3 (318 mg, 55percent).

31166-44-6, 31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference:
Article; Chen, Po-Ting; Lin, Wen-Po; Lee, An-Rong; Hu, Ming-Kuan; Molecules; vol. 18; 7; (2013); p. 7557 – 7569;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics