142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Weigh Trifluoromethyl acid 9.5g (0.05mol) was dissolved in 20ml of dry tetrahydrofuran, was slowly added CDI8.9g (0.055mol),At room temperature for 4hAfter the reaction solution through a dropping funnel was added dropwise to a solution of constant piperazine dihydrochloride 20g (0.125mol), anhydrous piperazine 10g (0.125mol), 60ml of an aqueous solution of sodium chloride, 14g, and reacted for 5 hours at room temperature .After completion of the reaction by suction, the filtrate evaporated removal of THF, treated 10ml ethyl acetate again, and then a saturated solution of NaOH was adjusted to pH = 10, extracted with ethyl acetate three times and the combined organic phases, the organic phase was dried over anhydrous sodium sulfate overnight, filtration, spin dry ethyl acetate, the resulting white crystals is 1- [3- (trifluoromethyl) benzoyl] crude 6.5g, 50% yield.
142-64-3, As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.
Reference：
Patent; Xi’an Jiaotong University; Zhang, Jie; Lu, Wen; Dong, Jinyun; Pan, Xiaoyan; He, Langchong; Zhang, Tao; Wang, Sicen; Shen, Xiuxiu; (16 pag.)CN104262238; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics