Downstream synthetic route of 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 58: 2-[2-( 4-methvl-piperazin-1-vl)-ethvlami no l-N-[3-( 5-thiophen-3-vl-pvrimidin-2-vlamino )- phenyl] acetamide; To a stirring solution of U (200 mg, 0.58 mmol) in CH3CN (100 mL) was added J (486 mg, 3.48 mmol) followed by diisopropylethylamine (300 muL, 1.74 mmol). The solution was brought to reflux and monitored by tic analysis. After 13 hours the solvent was removed in vacuo and the residue purified via column chromatography (silica gel, 9:1 CH2CI2/MeOH). The fractions containing product were evaporated to dryness under vacuum to yield compound 58 in 44percent yield as a white crystalline solid. 1H NMR (300 MHz, CDCl3) No. 2.27 (s, 3H), 2.27-2.46 (m, 10H), 2.5-2.54 (m, 2H), 3.39 (s, 2H), 7.2-7.46 (m, 11 H), 8.09 (s, 1 H), 8.67 (s, 2H), 9.42 (s, 1H). MS m/z 452 [M++1]., 934-98-5

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference:
Patent; SUGEN, INC.; WO2005/113548; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics