With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-81-3,1-Methyl-4-(4-nitrobenzyl)piperazine,as a common compound, the synthetic route is as follows.
Add 8.5 g (36.2 mmol) of crude I-a to a 500 mL one-necked flask. 2.0 g of FeO(OH)/C catalyst and 100 mL of 95% ethanol, Heating back, Slowly add a mixture of 25 mL of hydrazine hydrate and 20 mL of 95% ethanol. The disappearance of the starting material by TLC (methanol: chloroform = 1:15). Hot and suction filtration, The filter cake was washed twice with hot ethanol (30 mL x 2). The solvent was evaporated under reduced pressure to give a white solid. It was dried under vacuum to give (I-b) 6.7 g, yield: 90.3%. The product was directly fed to the next reaction without further purification.
70261-81-3, As the paragraph descriping shows that 70261-81-3 is playing an increasingly important role.
Reference：
Patent; China Pharmaceutical University; Wang Yue; Lu Shuai; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (26 pag.)CN109970717; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics