3022-15-9, Piperazine-2-carboxylic acid dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
N: l,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 25. To an aqueous solution of Na2C03 (40 g, 380 mmol, in 200 mL of water) at room temperature was added piperazine-2- carboxylic acid dihydro chloride (either an enantiomeric mixture or a specific stereoisomer) (24; 10 g, 50 mmol), followed by di-ieri-butyl dicarbonate (41 g, 183 mmol) in tetrahydrofuran (200 mL). The reaction mixture was stirred at room temperature for 20 hours and then the volatiles were removed under reduced pressure. The resulting mixture was then extracted with diethyl ether (100 mL). The aqueous layer was treated with 3.0 M HC1 until it was slightly acidic (pH = 4) and then extracted with ethyl acetate (150 mL). The organic layer was washed with brine, dried over anhy. Na2SC>4, filtered, and concentrated to afford 16 g of the title compound as a white solid., 3022-15-9
3022-15-9 Piperazine-2-carboxylic acid dihydrochloride 2723757, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong; WO2012/171506; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics