With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59878-57-8,1-(Cyclopropylcarbonyl)piperazine,as a common compound, the synthetic route is as follows.
At room temperature 1-cyclopropane carboxylic acid piperazine (2.37g, 15.37mmol) and p-formyl benzene boronic acid (1.92g, 12.81mmol) Was dissolved in dichloromethane (40ml), stirred for 1 hour at room temperature, again was added sodium cyanoborohydride (1.77g, 28.18mmol), Was stirred at room temperature until the reaction is complete as monitored by TLC, water was added 20ml, extracted with dichloromethane, washed with saturated brine twice, The organic phase was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, to give: (4-benzyl-acid – piperazin-1-yl) – cyclopropyl – methanone, (1.6 g of, White solid), yield: 43.4%, was used directly in the next reaction., 59878-57-8
The synthetic route of 59878-57-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SHANGHAI CDYMAXPHARMACEUTICALS CO LTD; An, Xiao Xia; Bie, Ping Yan; Liu, Jun; Yang, Wuli; (43 pag.)CN103087077; (2016); B;,
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