With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
(iii) 3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(methylsulfinyl)phenyl)ureido)naphthalen-1- yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(4-methylpiperazin-1-yl)ethyl)benzamideHATU (150 mg, 0.394 mmol) was added to a solution of the product from step (ii) above (200 mg, 0.284 mmol), 2-(4-methylpiperazin-1-yl)ethanamine (60 mg, 0.419 mmol) and diisopropylethylamine (150 L, 0.859 mmol) in DMF (2 mL). The reaction mixture was stirred at rt for 72h. Water (10 mL) added and the resulting solid filtered off, washed with water (2 mL) and dried to afford the title compound (0.19 g). 1H NMR (400 MHz, DMSO-ds) delta 9.41 (s, 1 H), 9.07 (s, 1 H), 8.96 (s, 1 H), 8.51 (d, 1 H), 8.28 (d, 1 H), 8.21 (t, 1 H), 8.12 (d, 1 H), 8.10 (d, 1 H), 7.88 (d, 1 H), 7.77-7.67 (m, 1 H), 7.66-7.58 (m, 1 H), 7.56 (t, 1 H), 7.50 (t, 1 H), 7.40 (d, 1 H), 7.36 (d, 1 H), 6.86 (dd, 1 H), 6.58 (dd, 1 H), 6.14 (d, 1 H), 3.87 (s, 3H), 3.74 (s, 3H), 2.79 (s, 3H), 2.43 (t, 2H), 2.32 (s, br, 10H), 2.15 (s, 3H), 1.32 (s, 9H). LCMS m/z 794 (M+H)+(ES+)
934-98-5, As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.
Reference：
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics