129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(2R,6S) and (2S,6R)-1,2,6-Trimethylpiperazine. To a solution of cis-3,5-dimethylpiperazine-1-carboxylic acid t-butylester (2.0 g, 9.22 mmol) in MeOH (25 mL), paraformaldehyde (0.84 g, 28 mmol) and zinc chloride (3.83 g, 28 mmol) were added. Then sodium cyanoborohydride (1.76 g, 28 mmol) was added in portions. The reaction mixture was stirred at rt. for 4 hr. Then insoluble solid was filtered out and the filtrated was concentrated. The residue was participated between saturated NaHCO3 solution and CH2Cl2 (2×50 mL). The organic layers were combined, dried (MgSO4) and concentrated to give a colorless oil. It was then dissolved in CH2Cl2 (10 mL) and TFA (2.5 mL) was added. The reaction mixture was stirred at rt. for overnight. TFA and solvent were evaporated to give a white solid as final product as TFA salt. (2.6 g, 86% yield); MS m/129(MH+). 1H NMR (500 MHz, CHLOROFORM-D) delta ppm 1.41 (d, J=6.41 Hz, 6H) 2.87 (s, 3H) 3.38-3.56 (m, 4 H) 3.71-3.90 (m, 2H).
129779-30-2, The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Bristol-Myers Squibb Company; US2007/270406; (2007); A1;,
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