With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485841-52-9,(S)-1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.,485841-52-9
75 mg (0.16 mmol) of 3-[(chloroacetyl)amino]-N-[6-(2-fluorophenyl)pyridin-3-yl]-4- (trifluoromethoxy)benzamide (intermediate 14) were dissolved in 0.69 mL of anh DMF. 4.1 mg (0.025 mmol) of potassium iodide, 0.042 mL (0.24 mmol) of N-ethyl-N-isopropylpropan-2-amine and 27.5 mg (0.24 mmol) of (2S)-l,2-dimethylpiperazine were added. It was stirred at rt overnight. The reaction mixture was concentrated to dryness under vacuum. The residue was purified by HPLC (method 2) yielding 34.5 mg (39%) of the title compound. XH-NMR (400 MHz, DMSO-d6): delta [ppm]= 1.01 – 1.12 (m, 3H), 2.09 – 2.45 (m, 5H, partly overlapping with the DMSO signal), 2.77 – 3.02 (m, 3H), 3.25 (br. s, 2H), 7.30 – 7.39 (m, 2H), 7.44 – 7.52 (m, 1H), 7.64 – 7.70 (m, 1H), 7.82 – 7.91 (m, 2H), 7.94 – 8.00 (m, 1H), 8.31 (dd, 1H), 8.75 – 8.81 (m, 1H), 9.07 (d, 1H), 9.91 (s, 1H), 10.75 (s, 1H). LC-MS (method 4): Rt = 0.99 min; MS (ESIpos): m/z = 546 [M+H]+.
As the paragraph descriping shows that 485841-52-9 is playing an increasingly important role.
Reference：
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William J.; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; WO2014/147021; (2014); A2;,
Piperazine – Wikipedia
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