170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of SK1-008 (8b, Scheme 3) (0.176 g, 0.6 mmol) and tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (0.167 g, 0.6 mmol) in 2-propanol (3 mL) was heated at 80 C in sealed tube for 40 h (monitored with HPLC-MS). The resulting precipitate was filtered upon cooling, and washed with 2- propanol (2 mL x 2), then dried under high vacuum to afford the title compound as a light greensolid (0.300 g, 88%). Mp.: 124 C (dec.); HPLC 98.5% (tR = 7.51 mm, 60% CH3OH in 0.1% TFA water, 20 mm); ?H NMR (400 MHz, DMSO-d6): oe 9.00 (s, 1H disappear on D20 shake), 7.94 (s, 1H), 7.53(d, J= 8.8 Hz, 2H), 6.84 (d, J= 8.8 Hz, 2H), 6.77 (brt, J= 5.6 Hz, 1H disappear on D20 shake), 4.10-4.03 (m, 1H), 3.78-3.73 (m, 1H), 3.63-3.58 (m, 1H), 3.43-3.40 (m, 6H), 2.96 (t, J= 4.8 Hz, 4H), 1.90-1.77 (m, 3H), 1.62-1.56 (m, 1H), 1.40 (s, 9H); LC-MS(ESI+) m/z 533.19, 535.19 (Br isotope); (M+H) HRMS (ESI+) m/z calculated for C24H34BrN6O3 (M+H) 533.1870, found 533.1862., 170911-92-9
170911-92-9 tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 11011301, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; MAHAJAN, Nupam, P.; MAHAJAN, Kiran, N.; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; WO2015/21149; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics