129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
131 6-(“(“3S.5RV3.5-Dimethyl-4-pyridin-2-ylmethyl-pirhoerazin-l-ylmethylV2-(lH- indazol-4-ylV4-mophiholin-4-yl-thienor3,2-dlpyrimidine.Via 2-Chloro-6-((3S,5R)-3,5-dimethyl-4-pyridin-2-ylmethyl-piperazin-l- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, prepared from (2S,6R)-2,6- dimethyl- l-pyridin-2-ylmethyl-piperazine. Amine preparation: (3R,5S)-3,5- dimethyl-piperazine-1-carboxylic acid tert-butyl ester (845mg), 2-(bromomethyl)- pyridine hydrobromide (Ig) and potassium carbonate (1.15g) was heated to reflux in MeCN (1OmL). After heating for 24 h the reaction mixture was diluted with DCM, washed with sodium bicarbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by flash chromatography to yield (3S,5R)-3,5- dimethyl-4-pyridin-2-ylmethyl-piperazine-l-carboxylic acid tert-butyl ester (867mg). Treatment of this compound with HCl in DCM/MeOH yielded the desired amine, which was isolated as the hydrochloride salt. 1H NMR (400MHz, CDCl3) 1.00 (d, J=6.0Hz, 6H), 1.54 (s, 2H), 2.05 (m, 2H), 2.84 (m, 4H), 3.81 (s, 2H), 3.92 (m, 4H), 4.10 (m, 4H), 7.11 (m, IH), 7.38 (s, IH), 7.51 (m, IH), 7.61 (m, 3H), 8.29 (d, J=7.4Hz, IH), 8.51 (d, J=4.5Hz, IH), 9.03 (s, IH); MS (ESI+) 555 (MH+).
129779-30-2, 129779-30-2 (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 10822535, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics