With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112984-60-8,6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
To a stirred solution of 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1H,4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (280 mg, 0.80 mmol) and triethylamine (0.3 ml , 2.16 mmol) in DMF(5 ml), compound C (570 mg, 1 mmol) was added and final solution was stuffed at room temperature for overnight. After completion, the solvent was evaporated, extracted with ethylacetate and washed with water. The organic extract was evaporated to obtain the crude mass which was further purified by flash column chromatography over silica gel using 2% methanol- DCM as eluent to obtain the compound D as an off white solid (220 mg, 48%). 1H NMR (DMSO-d6): 1H NMR (CDC13): isomer I: oe 14.66 (s,1H, COOH), 10.07 (s, 1H, NH), 8.66 (d, 1H, JAB= 1.5 Hz, ArH), 7.96 (s, 1H, ArH), 7.82 (d, 1H, JAB= 14.0 Hz, ArH), 7.70-7.66 (m, 1H, ArH), 6.95 (d, 1H, JAB= 7.0Hz, ArH), 6.40 (q, 1H, JAB = 6 Hz, SCHN), 3.44-3.37 (m, 4H, CH2N), 3.29 (s, 2H, CH2), 2.80-2.75(m, 4H, CH2N), 2.13 (d, 3H, JAB = 6.0 Hz, CH3), 1.64 (s, 9H, CH3), 1.36 (s, 18H, CH3); Isomer II: oe14.66 (s,1H, COOH), 10.01 (s, 1H, NH), 8.15 (d, 1H, JAB= 1.5 Hz, ArH), 7.90 (d, 1H, JAB= 9 Hz,ArH), 7.82 (d, 1H, JAB= 14.0 Hz, ArH), 7.70-7.66 (m, 1H, ArH), 7.51 (dd, 1H, JAB= 8.5 Hz, Jm= 1.5Hz,ArH), 6.95 (d, 1H, JAB= 7.0 Hz, ArH), 6.40 (q, 1H, JAB = 6 Hz, SCHN), 3.44-3.37 (m, 4H,CH2N), 3.29 (s, 2H, CH2), 2.80-2.75 (m, 4H, CH2N), 2.13 (d, 3H, JAB = 6.0 Hz, CH3), 1.64 (s, 9H,CH3), 1.36 (s, 18H, CH3)., 112984-60-8
The synthetic route of 112984-60-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
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