With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
General Procedure: To a 75 mL screw-cap round bottom flask equipped with a stir bar were added l-bromo-2,4-dichlorobenzene (0.72 mL, 5.99 mmol), 3-methyl-piperazine-l-carboxylic acid tert-butyl ester (1.0 g, 4.99 mmol), 2-di-tert-butylphosphino-2′-(N,N- dimethylamine)biphenyl (51.1 mg, 0.15 mmol), tris(dibenzylideneacetone)dipalladium (45.7 rag, 0.05 mmol) and tetrahydrofuran (30 mL). The reaction flask was flushed with nitrogen for 5 minutes and then lithium bis(trimethylsilyl)amide (1 M in tetrahydrofuran, 6.99 mL, 6.99 mmol) was added in one portion. The reaction flask was sealed and the reaction mixture was stirred at room temperature for 72 hours. The reaction mixture was concentrated in vacuo and the residue purified on silica gel using hexanes: acetone = 98:2 to give the desired product as an off-white solid (130 mg, 8 percent). 1H NMR (300 MHz, CDCl3): delta 6.77 (t, IH)5 6.68 (d, 2H)5 4.10 (bs, IH), 3.85 (bss 2H), 3.12 (m, 4H). 1.48 (s, 9H), 1.04 (d, 3H).
120737-59-9, The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
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