5521-39-1, 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
mCPBA (<77% pure) (102 mg, assumed 0.455 mmol) in DCM (0.5 mL) was added to a stirred solution of 6- (2,6- dichlorophenyl ) -2 - (methylthio) pyrido [4 , 3 -d] pyrimidin-5 ( 6H) - one (100 mg, 0.296 mmol) in toluene (3.0 mL) at RT undernitrogen. After 15 min, DIPEA (0.155 mL, 0.887 mmol) and 2- (4 - (4 -aminophenyl ) iperazin- 1 -yl ) ethanol (65.4 mg, 0.296 mmol) [commercially available] were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture was cooled and loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane) to give material that required further purification by preparative HPLC . The pure fractions were concentrated to give the title compound (39.8 mg, 26%) as a yellow solid. LCMS (Method A): RT = 0.80 min, m/z = 511, 513 [M+H]+. 1U NMR (500 MHz, methanol -d4 ) : delta 9.19 (s, 1H) , 7.70-7.60 (m, 4H) , 7.52 (dd, 1H) , 7.47 (d, 1H) , 7.02 (d, 2H) , 6.60 (d, 1H) , 3.75 (t, 2H) , 3.23 (t, 4H) , 2.77 (m, 4H) , 2.66 (t , 2H) . 5521-39-1, 5521-39-1 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol 767100, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin Roderick; ROUNTREE, James Samuel Shane; BURKAMP, Frank; WILKINSON, Andrew John; WO2014/167347; (2014); A1;,
Piperazine – Wikipedia
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