170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
p-Nitrophenyl chloroformate (4.16 g) and pyridine (2.0 mL) were added to a solution of N-tert-butyloxycarbonyl-N’-(4-aminophenyl)-piperazine (5.54 g) in anhydrous tetrahydrofuran (40 mL) at 0C. The reaction mixture was stirred at 0C for one hour and stirred at room temperature for three hours and diluted with 1N hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was washed with a saturated sodium hydrogen carbonate aqueous solution and saturated brine, dried over sodium sulfate and concentrated. The obtained solid was collected by filtration and dried and 6.42 g (72%) of the title compound was obtained as a pale yellow solid. 1H NMR(400MHz,DMSO-d6):delta(ppm)=8.26(2H, d, J=9.OHz), 7.37(2H, d, J=9.0Hz), 7.34(2H, d, J=9.OHz), 6.97(IH, brs), 6.92(2H, d, J=9.OHz), 3.58(4H, t, J=5.1Hz), 3.10(4H, t, J=5.1Hz), 1.48(9H, s).
170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Sankyo Company, Limited; EP1764360; (2007); A1;,
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