Analyzing the synthesis route of 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

5747-48-8, 11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5747-48-8, A solution of but-3-yn-2-one (1 mmol) and PDBTZ (1 mmol), in ethyl acetate (10 mL) is refluxed for two hours. The reaction mixture is washed (water, brine), dried (sodium sulfate), and evaporated. The crude material is purified by flash chromatography to provide the enamine product.

The synthetic route of 5747-48-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2008/79847; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics