With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.
4-Cyclopentyl-piperazine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester. The hydrochloride of the title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-cyclopentyl-piperazine. White solid, m.p. 294-295 C.; HPLC-MS m/z=436 (M+H), Rt: 2.92 min.; 1H NMR (DMSO-d6): delta 11.15 (br, 1H, NH), 8.60-8.55 (br, 1H, py-H6), 8.29-8.20 (m, 1H, py-H4), 7.32-7.21 (d+br s, 5H, py-H3+C6H4), 4.35-3.98 (br, 2H), 3.72-3.37 (br m, 5H), 3.29-2.97 (br, 2H), 2.12-1.45 (br m, 8H).
21043-40-3, The synthetic route of 21043-40-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
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