112984-60-8, 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of DCC (0.9 g, 4.3 mmol)in DMF (20 ml), BOC-glycine (0.5 g, 2.85 mmol) and hydroxybenzotriazole (HOBt, 0.5 g, 4.3mmol) were added at 0 C and the mixture was allowed to stir for 4 h, followed by addition of 6-fluoro- 1 -methyl-7-(4-((5-nitro- 1H-benzo[d]imidazol-2-yl)methyl)piperazin- 1 -yl)-4-oxo- 1H,4H- [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (0.9 g, 2.85 mmol) and triethylamine (0.4 g, 0.6 ml 4.3 mmol) at 0 C. The reaction mixture was allowed to stir for overnight at room temperature. After completion, the final solution was then concentrated under reduced pressure to obtain the crudeproduct which was purified by flash column chromatography over silica gel using 3% methanolDCM as eluent to afford compound A as pale yellow solid (0.75g, yield: 65%).1H NMR (DMSO-d6):oe 14.62 (brs, 1H, COOH), 7.84 (d, 1H, JAB = 14.0 Hz, ArH), 6.95 (d, 1H, JAB = 7.0 Hz, ArH), 6.81 (t, 1H, JAB = 6.0 Hz, NH), 6.39 (q, 1H, JAB = 6.5 Hz, SCHN), 3.85 (d, 2H, JAB = 6.0 Hz, CH2), 3.64-3.56 (m, 4H, CH2N), 2.12 (d, 3H, JAB = 6.0 Hz, CH3). ESI-MS (mlz): 495.16 (M+H).
112984-60-8, The synthetic route of 112984-60-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics