Downstream synthetic route of 169447-86-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169447-86-3,(S)-tert-Butyl 2-benzylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step A: Amination of halopyrazine; Preparation of 2-amino-5-bromo-3-r(S)-4-Boc-3-benzylpiperazinyllpyrazine 108; To a solution of 2-arnino-3,5-dibromopyrazine 106 (0.2 g, 0.79 mmol.) and (S)- 1 -Boc-2-benzylpiperazine 107 (0.44 g, 1.59 mmol) in dioxane (2 ml_) and trifluoromethylbenzene (2 ml_) was added diisopropylethylamine (0.31 g, 2.4 mmol). The reaction mixture was heated in a microwave reactor at 210 0C for 20 minutes. Ethyl acetate (100 ml_) was added. The organic layer was washed with water and brine. The organic layer was dried over sodium sulfate. The organic solvent was evaporated under reduced pressure. The crude product was purified by RP-HPLC to yield the desired 2-amino-5-bromo-3-[(S)-4-Boc-3-benzylpiperazinyl]pyrazine 108 (0.24 g, 0.536 mmol).

169447-86-3, 169447-86-3 (S)-tert-Butyl 2-benzylpiperazine-1-carboxylate 17750441, apiperazines compound, is more and more widely used in various fields.

Reference：
Patent; SCHERING CORPORATION; WO2007/126964; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics