With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.150407-69-5,(S)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Step A – Preparation of Int Int 48-1 To a solution of piperazine carboxylic acid (10 g, 27 mmol) in DCM (50 mL) was added TEA (2.39 mL, 54 mmol) and HATU (11.4 g, 30 mmol) with stirring. The reaction mixture was stirred at room temperature for 30 mins then treated with piperidine (2.57 g, 30 mmol). The reaction solution was stirred for 48 hrs then concentrated. The residue was purified by column chromatography on silica gel eluted with petroleum ether / EtOAc (3 : 1) to afford compound Int 48-1 as yellow oil (10.7g). MS-ESI (m/z): 432 (M+l)+ R 0.6 (PE : EtOAc= 1 : 1) H NMR (CDC13) delta: 7.30-7.24 (m, 5H), 5.25 (s, 1H), 5.14 (d, J=12.3 Hz, 1H), 5.06-4.98 (m, 1H), 4.18-3.80 (m, 5H), 3.41 (s, 2H), 3.21 (d, J=13 Hz, 3H), 1.61 (s, 2H), 1.52 (t, J7=16.6 Hz,, 150407-69-5
As the paragraph descriping shows that 150407-69-5 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME CORP.; COBURN, Craig, A.; MALETIC, Milana, M.; LUO, Yunfu; QI, Zhiqi; YU, Tingting; SOLL, Richard; WO2015/73310; (2015); A1;,
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