With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.
To the 25 ml round-bottom flask by adding 69A (159mul, 1mmol) and dichloromethane, after stirring to dissolve by adding 69B (270 mg, 1mmol), then adding STAB (254 mg, 1 . 2mmol) stirring overnight, TLC detection reaction is complete, water washing, the water layer is extracted with ethyl acetate, combined with the phase, saturated salt water washing, dry anhydrous sodium sulfate, concentrated after the silica gel to obtain the product 69 (217 mg, 56%).
21043-40-3, 21043-40-3 1-Cyclopentylpiperazine 806421, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Chengdu Biological Technology Co., Ltd. Kerry Bass; Li, Dequn; (92 pag.)CN105777632; (2016); A;,
Piperazine – Wikipedia
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