154590-35-9, tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of the product of EXAMPLE 13A (70 mg, 0.21 mmol), ieri-butyl 4-(4- amino-2-fluorophenyl)piperazine- l -carboxylate (61 mg, 0.21 mmol) and catalytic p- toluenesulfonic acid (5 mg) in w-butanol (3 mL) was heated at 100C for 18 hours. After cooling to ambient temperature, the mixture was poured into saturated aqueous sodium bicarbonate (50 mL). The resulting solution was extracted with ethyl acetate (3 x 30 mL), and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography using 20: 1 dichloromethane/methanol to afford the crude title compound which was used in the next step without further purification. MS: 598 (M+H+).
154590-35-9, The synthetic route of 154590-35-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97683; (2012); A1;,
Piperazine – Wikipedia
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