With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228780-72-0,1-((4′-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine,as a common compound, the synthetic route is as follows.
Example 33G ethyl 2-(1H-indol-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate EXAMPLE 33A (225 mg), EXAMPLE 33F (240 mg), and HK2PO4 (131 mg) were stirred in dimethylsulfoxide (4 mL) at 135 C. for 24 hours. The reaction was diluted with ethyl acetate, washed three times with water, washed with brine, dried, and concentrated. The crude product was chromatographed on silica gel with 30% ethyl acetate/hexanes., 1228780-72-0
As the paragraph descriping shows that 1228780-72-0 is playing an increasingly important role.
Reference：
Patent; ABBOTT LABORATORIES; US2010/184766; (2010); A1;,
Piperazine – Wikipedia
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