78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78818-15-2
b) 2-Bromoethyl di-tert-butyl phosphate (298mg, 0. 94MMOL) in tetrahydrofuran (1. 0ml) was added at room temperature to a stirred suspension of benzyl 3-oxopiperazine-1- carboxylate (200mg, 0. 85mmol), powdered potassium hydroxide (57mg, L. OMMOL) and tetra- n-butylammonium bromide (55mg, 0.17mmol) in THF (2. 0ml). The reaction mixture was -266- stirred for 90 minutes and then filtered through Celite and the filtrate evaporated to leave a colourless oil. The crude product was purified by silica gel chromatography eluting with a 2- 5% mixture of methanol in dichloromethane to give benzyl 4-{2-[(DI-TERT- butoxyphosphoryl) oxy] ETHYL}-3-OXOPIPERAZINE-1-CARBOXYLATE (220 mg, 55% yield) as a colourless oil: 1H-NMR (CDC13) : 7.34 (m, 5H), 5.16 (s, 2H), 4.15 (s, 2H), 4.11 (m, 2H), 3.71 (m, 2H), 3.65 (m, 2H), 3.53 (m, 2H), 1.47 (s, 18H).
The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/94410; (2004); A1;,
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