34334-28-6, 4-(4-Methylpiperazin-1-yl)benzonitrile is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4- (4-methylpiperazin-1-yl) benzonitrile (200 mg, 1 mmol) in anhydrous tetrahydrofuran (2.0 mL) under nitrogen was added methyl magnesium bromide (3.3 mL, 3 M 2- Methyl tetrahydrofuran solution), the reaction system was placed in a microwave reactor and stirred at 100 C for 10 minutes.Then the reaction system was cooled to room temperature, and methylmagnesium bromide (0.7 mL, 3M 2-methyltetrahydrofuran solution) and titanium tetraisopropoxide (570 mg, 2.0 mmol) were added to the system, and the reaction system was placed in a microwave reaction. Stir at 50 C for 30 minutes.Cool to room temperature and quench the reaction with water. After extraction with ethyl acetate, the organic phase was concentrated under reduced pressure and purified by flash column chromatography (dichloromethane / methanol = 95/5) to obtain 2- (4- (4-methylpiperazine). Azin-1-yl) phenyl) propan-2-amine (1A, 50 mg, yield 21%) was a brown solid.
34334-28-6, The synthetic route of 34334-28-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Shanghai Dinuo Pharmaceutical Technology Co., Ltd.; Zhao Zhiming; (42 pag.)CN110467629; (2019); A;,
Piperazine – Wikipedia
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