4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
[18041 Step 1: Synthesis of methyl4-(((3R.55?)-4-(3-((4-isopropylpiperazin- 1 -yflmethyflbenzyfl-3.5-dimethylpiperazin- 1- yl?)methyflbenzoate[18051 Methyl 4-(((3R,55)-4-(3-formylbenzyl)-3 ,5-dimethylpiperazin- 1 -yl)methyl)benzoate (formula 5-1, 0.200 g, 0.526 mmol) and 1-isopropylpiperazine (0.113 mL, 0.788 mmol) were dissolved in methylene chloride (4 mL), and the solution was stirred at room temperature for 1 hour. Na(OAc)3BH (0.223 g, 1.051 mmol) was added to the solution, followed by stirring at the same temperature for 17 hours. Then, a saturated aqueous solution of sodium hydrogen carbonate was added to the reaction mixture, followed by extraction with methylene chloride. The extract was filtered through a plastic filter to remove solid residue and an aqueous layer, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide, 4 g cartridge; methanol/methylene chloride = from 0 percent to 10 percent) and concentrated to afford the desired compound (0.225 g, 86.9 percent) as a pale brown oil.
As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.
Reference：
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
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