With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,170911-92-9
A solution of 2-chloro-6-(2-chlorophenyl)-5H-pyrano[2,3-d]pyrimidin-5-one (42 mg, 0.14 mmol), tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (40 mg,0.14 mmol) and DIPEA (50 1JL, 0.29 mmol) in anhydrous DMF (1 mL) was heated to 100 C under a nitrogen atmosphere for 60 mm. The reaction mixture was allowed to cool to RT, diluted with water (5 mL) and extracted into ethyl acetate (3 x 5 mL) . The combined organic phases werewashed with 1:1 water/brine (3 x 5 mL), dried over Na2504, filtered, and concentrated to dryness under reduced pressure. The residue was purified by flash chromatography (10-100%, MeOH in DCM) to give the title compound (50 mg, 65%) as a brown solid. ?H NMR (500 MHz,CDC13) : 6 9.24 (s, 1H), 7.94 (br s, 1H), 7.80 (s, 1H),7.54 (br d, 2H), 7.49 (dd, 1H), 7.30-7.38 (m, 3H), 6.96(d, 2H), 3.59 (t, 4H), 3.13 (t, 4H), 1.49 (s, 9H) . LCMS(Method A) : = 1.52 mi m/z = 534, 536 [M+H].
As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.
Reference：
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics