159532-59-9, (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step C (S)-1-(tert-Butyloxycarbonyl)-4-(dipentylcarbamoyl)piperazine-2-carboxylic acid A partial solution of 1.32 g (5.74 mmole) of (S)-1-(tert-butyloxycarbonyl)piperazine-2-carboxylic acid in 25 ml of dried DMF was treated dropwise over 5 min with 1.48 g (11.47 mmole of diisopropylethyl amine at 25 under nitrogen with stirring. The clear solution which resulted was treated dropwise over 15 min with a solution of 1.26 g (5.74 mmole) of dipentylcarbamoyl chloride in 5 ml of DMF and the mixture was stirred under nitrogen at 25 for 16 hr. The solution was concentrated in vacuo and the residue was dissolved in 100 ml of dichloromethane which was extracted with 2*100 ml of 0.5M citric acid and 2*25 ml of water. Without drying, the solution was concentrated in vacuo to 1.85g (78%) of medium yellow oil which was homogeneous by the (silica gel, 1:1:1:1 ethylacetate: n-butanol: acetic acid: water, Rf =0.50). Mass Spectrum (FAB): m/e 414 (M+1), 358 (loss of butyl) 1 H NMR (CDCl3, 400 MHz, ppm): delta0.86 (t, 6H), 1.20 (m, 4H), 1.27 (m, 4H), 2.46 (m, 13H), 2.82 (m, 1H), 3.10 (m, 4H), 3.16 (m, 2H), 3.42 (d of d, 1H), 3.84 (d of d, 1H), 4.04 (d, 1H), 4.61-4.77 (d, 1H).
159532-59-9, As the paragraph descriping shows that 159532-59-9 is playing an increasingly important role.
Reference：
Patent; Merck & Co., Inc.; US5348955; (1994); A;,
Piperazine – Wikipedia
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