5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5271-27-2, To a 1000 ml three-necked flask, 600 ml of N, N-dimethylformamide and 2-chloronicotinamide (153 g, 0.98 mol) were added.1-methyl-3-phenylpiperazine (172 g, 0.98 mol) and potassium fluoride (114 g, 1.96 mol) were added and the mixture was heated to 140 ° C and stirred for 16 hours. The crude product was added to 1000 ml of ice water, stirred for 1 hour, Isolated by filtration to give a white solid. The white solid was further dried by blowing with air at 50 ° C to give 261 g of 2-(4-methyl-2-phenyl-1-piperazinyl)nicotinamide as a white solid in a yield of 90percent.
The synthetic route of 5271-27-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Liu Jinai; Li Yuanzhen; Ning Ruibo; Wang Mingxin; (8 pag.)CN105367571; (2017); B;,
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