314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
fe/f-Butyl (S)-3-(hydroxymethyl)piperazine-1 – carboxylate (6.4 mg, 0.0295 mmol) was added to a stirred solution of Acid 4 (15.0 mg, 0.0295 mmol), HATU (13.5 mg, 0.0354 mmol) and DIPEA (0.016 ml_, 0.0885 mmol) in DCM (5.0 mL) at RT. After 22 h, further fe/f-butyl (S)-3-(hydroxymethyl)piperazine-1 -carboxylate (2.1 mg, 0.00983 mmol) was added. After a further 4 h, saturated sodium bicarbonate (aq) solution and further DCM were added and the resulting biphasic mixture was separated, extracted (x 2), the combined organic phase was dried (phase separator), the solvents were removed in vacuo, and the remaining residue was purified by flash chromatography using an 1 1 g KP-NH column (0- 100%, EtOAc in cyclohexane) to give the title compound (12.8 mg, 61 %) as a white solid. LCMS (Method A): RT = 1.64 min, m/z = 707 [M+H]+.
314741-40-7, The synthetic route of 314741-40-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ALMAC DISCOVERY LIMITED; HEWITT, Peter; MCFARLAND, Mary Melissa; ROUNTREE, James Samuel Shane; BURKAMP, Frank; BELL, Christina; PROCTOR, Lauren; HELM, Matthew Duncan; O’DOWD, Colin; HARRISON, Timothy; (280 pag.)WO2018/20242; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics