78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78818-15-2
In a sealed tube, dissolve benzyl 3-oxopiperazine-l-carboxylate (500 mg, 2.13 mmol), A- bromo-acetophenone (425 mg, 2.13 mmol), Cs2CO3 (1.4 g, 4.26 mmol), Pd2dba3 (195 mg, 0.213 mmol) and xantphos (124 mg, 0.213 mmol) in dry dioxane (10 mL). Degas the mixture with Argon and heat at 115 0C overnight. Cool and dilute with EtOAc (25 mL). Filter the solution through Ce lite and evaporate the filtrate. Chromatograph the crude product on silica eluting with hexane/acetone (2: 1) to yield the title compound. LC-MS (M+l): 353.14
The synthetic route of 78818-15-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NEUROGEN CORPORATION; WO2007/16496; (2007); A2;,
Piperazine – Wikipedia
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